Flexibility in the ABC Transporter MsbA: Alternating Access with a Twist

ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a wide variety of substrates across cellular membranes and are conserved from bacteria to humans. Here we compare four x-ray structures of the bacterial ABC lipid flippase, MsbA, trapped in different conformation...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (48), p.19005-19010
Hauptverfasser:	Ward, Andrew, Reyes, Christopher L., Yu, Jodie, Roth, Christopher B., Chang, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism Adenylyl Imidodiphosphate - metabolism Amino Acid Sequence ATP binding cassette transporters ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - metabolism Bacteria Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Biochemistry Biological Sciences Biological Transport, Active Comparative analysis Crystallography, X-Ray Cytoplasm Dimers Electrical phases Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Flexibility Lipids Membranes Models, Molecular Molecular Sequence Data Molecules Monomers Motion Nucleotides Protein Binding Protein Conformation Salmonella typhimurium - chemistry Sequence Alignment Sequence Homology, Amino Acid Species Specificity Vibrio cholerae - chemistry
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