Antibodies to CD4-Induced Sites in HIV gp120 Correlate with the Control of SHIV Challenge in Macaques Vaccinated with Subunit Immunogens

Epitopes located in and around the coreceptor binding site of HIV-1 envelope glycoprotein (gp120) exhibit enhanced exposure after attachment to the CD4 receptor and comprise some of the most conserved and functionally important residues on the viral envelope. Therefore, antibody responses to these e...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (44), p.17477-17482
Hauptverfasser:	DeVico, Anthony, Fouts, Timothy, Lewis, George K., Gallo, Robert C., Godfrey, Karla, Charurat, Manhattan, Harris, Ilia, Galmin, Lindsey, Pal, Ranajit
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - immunology Animals Antibodies Antibodies, Monoclonal - immunology Antigens Binding sites Biological Sciences CD4 Antigens - immunology Cell Line Cells Epitopes Glycoproteins HIV HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infections Lentivirus Infections - genetics Lentivirus Infections - immunology Macaca - immunology Macaca mulatta Monkeys & apes RNA, Viral - genetics Shivs Simian Immunodeficiency Virus - immunology Simian/human immunodeficiency virus Vaccination Vaccines Vaccines, Subunit - immunology Viral RNA Viremia
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