Genetic Triple Dissociation Reveals Multiple Roles for Dopamine in Reinforcement Learning

What are the genetic and neural components that support adaptive learning from positive and negative outcomes? Here, we show with genetic analyses that three independent dopaminergic mechanisms contribute to reward and avoidance learning in humans. A polymorphism in the DARPP-32 gene, associated wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (41), p.16311-16316
Hauptverfasser:	Frank, Michael J., Moustafa, Ahmed A., Haughey, Heather M., Curran, Tim, Hutchison, Kent E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Algorithms Biological Sciences Brain Brain - physiology Catechol O-Methyltransferase - genetics Dopamine - genetics Dopamine - physiology Dopamine and cAMP-Regulated Phosphoprotein 32 - genetics Female Genetics Genetics, Behavioral Genotypes Human genetics Humans Learning Learning modules Learning rate Male Maximum likelihood method Medical genetics Models, Genetic Models, Psychological Negative feedback Neurons Neurotransmitters Polymorphism Polymorphism, Genetic Positive feedback Receptors Receptors, Dopamine D2 - genetics Reinforcement (Psychology) Social Sciences Working memory
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