MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs. normal lung, although the significance of this aberrant expressi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (40), p.15805-15810
Hauptverfasser:	Fabbri, Muller, Garzon, Ramiro, Cimmino, Amelia, Liu, Zhongfa, Zanesi, Nicola, Callegari, Elisa, Liu, Shujun, Alder, Hansjuerg, Costinean, Stefan, Fernandez-Cymering, Cecilia, Volinia, Stefano, Guler, Gulnur, Morrison, Carl D, Chan, Kenneth K, Marcucci, Guido, Calin, George A, Huebner, Kay, Croce, Carlo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Carcinogenesis Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Cell lines Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation DNA Methyltransferase 3A DNA Methyltransferase 3B DNA, Neoplasm - genetics epigenetics Gene expression gene expression regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genes Humans Lung - enzymology Lung cancer Lung neoplasms Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - mortality Messenger RNA Methylation methyltransferases MicroRNA MicroRNAs - genetics non-coding RNA Oligonucleotides Oncology Prognosis Ribonucleic acid RNA RNA, Neoplasm - genetics Survival Analysis tissues Transfection tumor suppressor genes Tumors
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