Huntingtin facilitates dynein/dynactin-mediated vesicle transport

Cytoplasmic dynein is a multisubunit microtubule motor complex that, together with its activator, dynactin, drives vesicular cargo toward the minus ends of microtubules. Huntingtin (Htt) is a vesicle-associated protein found in both neuronal and nonneuronal cells that is thought to be involved in ve...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-06, Vol.104 (24), p.10045-10050
Hauptverfasser:	Caviston, Juliane P, Ross, Jennifer L, Antony, Sheila M, Tokito, Mariko, Holzbaur, Erika L.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Animals Antibodies Biochemistry Biological Sciences Biological Transport Brain Brain Chemistry Brain research Cattle Cellular immunity Chromatography, Affinity Cytoplasmic Vesicles - metabolism Cytosol Cytosol - enzymology Dyneins - chemistry Dyneins - isolation & purification Dyneins - metabolism Freight Golgi Apparatus - drug effects HeLa Cells Humans Huntingtin Protein Immunohistochemistry Mice Mice, Transgenic Microtubules Microtubules - enzymology Microtubules - metabolism Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Neurons Nuclear Proteins - metabolism Nuclear Proteins - pharmacology Precipitin Tests Proteins RNA RNA Interference Rodents Sensitivity and Specificity Two-Hybrid System Techniques Yeasts
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