Lipidomics Reveals Control of Mycobacterium tuberculosis Virulence Lipids via Metabolic Coupling

Mycobacterium tuberculosis synthesizes specific polyketide lipids that interact with the host and are required for virulence. Using a mass spectrometric approach to simultaneously monitor hundreds of lipids, we discovered that the size and abundance of two lipid virulence factors, phthiocerol dimyco...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (12), p.5133-5138
Hauptverfasser:	Jain, Madhulika, Petzold, Christopher J., Schelle, Michael W., Leavell, Michael D., Mougous, Joseph D., Bertozzi, Carolyn R., Leary, Julie A., Cox, Jeffery S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - pharmacology Animals Bacteria Bacteriology Biochemistry Biological Sciences Cell culture Cell growth Chemical synthesis Fatty acids Fatty Acids - chemistry Fatty Acids - pharmacology Infections Lipid metabolism Lipid Metabolism - drug effects Lipids Lipids - biosynthesis Lipids - chemistry Lungs Mass spectrometry Metabolism Mice Mice, Inbred BALB C Molecular Weight Mutation - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Pathology Propionates Propionates - pharmacology Rodents Tuberculosis Tuberculosis - chemically induced Virulence Virulence - drug effects
Online-Zugang:	Volltext
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