TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (11), p.4700-4705 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4705 |
|---|---|
| container_issue | 11 |
| container_start_page | 4700 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 104 |
| creator | Kovács, Krisztián A Steullet, Pascal Steinmann, Myriam Do, Kim Q Magistretti, Pierre J Halfon, Olivier Cardinaux, Jean-René |
| description | A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus. |
| doi_str_mv | 10.1073/pnas.0607524104 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pnas_</sourceid><recordid>TN_cdi_pnas_primary_104_11_4700</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25426896</jstor_id><sourcerecordid>25426896</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-dddcc2be5b5e96afdd0c5ebff1ee2a41c8d240171382e140cdbdad2220a29ba83</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhzAmwOCAuacdO4iQXpGrFl1RUBO3ZcuzJ1ivHTmNnxf57vOyqCxzgNCP5mXc-XmfZcwpnFOrifHQynAGHumIlhfJBtqDQ0pyXLTzMFgCszpuSlSfZkxDWANBWDTzOTmhdcKiaepHdXV99W1JiApFESavMPOREOk3UxZeveUAXTDQbJMobp4xGp5BojKiin4hxG283qFNCbs04eiWHUVpivVvlEaeBhK2TYzSKjFaGFE3cPs0e9dIGfHaIp9nNh_fXy0_55dXHz8uLy1xx2sRca60U67DqKmy57LUGVWHX9xSRyZKqRrMSaE2LhiEtQelOS80YA8naTjbFafZurzvO3YBaoYuTtGKczCCnrfDSiD9fnLkVK78RtCkazosk8OYgMPm7GUMUgwkKrZUO_RxEna7LGbD_grTllBfQJvD1X-Daz5NLVxAMaNEmNUjQ-R5Skw9hwv5-ZApiZ7rYmS6OpqeKl79veuQPLifg1QHYVR7lSkGpKOtfTd_-mxD9bG3EHzGhL_boOqQ_cM-yqmS8afmxWS-9kKvJBHHzfbcepIHrGoriJ0W11ag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201396200</pqid></control><display><type>article</type><title>TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Kovács, Krisztián A ; Steullet, Pascal ; Steinmann, Myriam ; Do, Kim Q ; Magistretti, Pierre J ; Halfon, Olivier ; Cardinaux, Jean-René</creator><creatorcontrib>Kovács, Krisztián A ; Steullet, Pascal ; Steinmann, Myriam ; Do, Kim Q ; Magistretti, Pierre J ; Halfon, Olivier ; Cardinaux, Jean-René</creatorcontrib><description>A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0607524104</identifier><identifier>PMID: 17360587</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Active Transport, Cell Nucleus ; Animals ; Binding sites ; Biochemistry ; Biological Sciences ; Brain ; Calcineurin - metabolism ; Calcium ; Cloning ; Coincidence ; Cyclic AMP - metabolism ; Cyclic AMP Response Element-Binding Protein - metabolism ; Genes ; Hippocampus - metabolism ; Long term potentiation ; Male ; Memory ; Mice ; Neurons ; Neurons - metabolism ; Phosphorylation ; Plasmids ; Protein synthesis ; Rats ; Recombinant proteins ; RNA, Messenger - metabolism ; Synapses ; Torcs ; Trans-Activators - physiology ; Transcription Factors - metabolism ; Transcription Factors - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (11), p.4700-4705</ispartof><rights>Copyright 2007 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Mar 13, 2007</rights><rights>2007 by The National Academy of Sciences of the USA 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-dddcc2be5b5e96afdd0c5ebff1ee2a41c8d240171382e140cdbdad2220a29ba83</citedby><cites>FETCH-LOGICAL-c618t-dddcc2be5b5e96afdd0c5ebff1ee2a41c8d240171382e140cdbdad2220a29ba83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/104/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25426896$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25426896$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17360587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovács, Krisztián A</creatorcontrib><creatorcontrib>Steullet, Pascal</creatorcontrib><creatorcontrib>Steinmann, Myriam</creatorcontrib><creatorcontrib>Do, Kim Q</creatorcontrib><creatorcontrib>Magistretti, Pierre J</creatorcontrib><creatorcontrib>Halfon, Olivier</creatorcontrib><creatorcontrib>Cardinaux, Jean-René</creatorcontrib><title>TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.</description><subject>Active Transport, Cell Nucleus</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Calcineurin - metabolism</subject><subject>Calcium</subject><subject>Cloning</subject><subject>Coincidence</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>Genes</subject><subject>Hippocampus - metabolism</subject><subject>Long term potentiation</subject><subject>Male</subject><subject>Memory</subject><subject>Mice</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Phosphorylation</subject><subject>Plasmids</subject><subject>Protein synthesis</subject><subject>Rats</subject><subject>Recombinant proteins</subject><subject>RNA, Messenger - metabolism</subject><subject>Synapses</subject><subject>Torcs</subject><subject>Trans-Activators - physiology</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhzAmwOCAuacdO4iQXpGrFl1RUBO3ZcuzJ1ivHTmNnxf57vOyqCxzgNCP5mXc-XmfZcwpnFOrifHQynAGHumIlhfJBtqDQ0pyXLTzMFgCszpuSlSfZkxDWANBWDTzOTmhdcKiaepHdXV99W1JiApFESavMPOREOk3UxZeveUAXTDQbJMobp4xGp5BojKiin4hxG283qFNCbs04eiWHUVpivVvlEaeBhK2TYzSKjFaGFE3cPs0e9dIGfHaIp9nNh_fXy0_55dXHz8uLy1xx2sRca60U67DqKmy57LUGVWHX9xSRyZKqRrMSaE2LhiEtQelOS80YA8naTjbFafZurzvO3YBaoYuTtGKczCCnrfDSiD9fnLkVK78RtCkazosk8OYgMPm7GUMUgwkKrZUO_RxEna7LGbD_grTllBfQJvD1X-Daz5NLVxAMaNEmNUjQ-R5Skw9hwv5-ZApiZ7rYmS6OpqeKl79veuQPLifg1QHYVR7lSkGpKOtfTd_-mxD9bG3EHzGhL_boOqQ_cM-yqmS8afmxWS-9kKvJBHHzfbcepIHrGoriJ0W11ag</recordid><startdate>20070313</startdate><enddate>20070313</enddate><creator>Kovács, Krisztián A</creator><creator>Steullet, Pascal</creator><creator>Steinmann, Myriam</creator><creator>Do, Kim Q</creator><creator>Magistretti, Pierre J</creator><creator>Halfon, Olivier</creator><creator>Cardinaux, Jean-René</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070313</creationdate><title>TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity</title><author>Kovács, Krisztián A ; Steullet, Pascal ; Steinmann, Myriam ; Do, Kim Q ; Magistretti, Pierre J ; Halfon, Olivier ; Cardinaux, Jean-René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-dddcc2be5b5e96afdd0c5ebff1ee2a41c8d240171382e140cdbdad2220a29ba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Active Transport, Cell Nucleus</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Biochemistry</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>Calcineurin - metabolism</topic><topic>Calcium</topic><topic>Cloning</topic><topic>Coincidence</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>Genes</topic><topic>Hippocampus - metabolism</topic><topic>Long term potentiation</topic><topic>Male</topic><topic>Memory</topic><topic>Mice</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Phosphorylation</topic><topic>Plasmids</topic><topic>Protein synthesis</topic><topic>Rats</topic><topic>Recombinant proteins</topic><topic>RNA, Messenger - metabolism</topic><topic>Synapses</topic><topic>Torcs</topic><topic>Trans-Activators - physiology</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovács, Krisztián A</creatorcontrib><creatorcontrib>Steullet, Pascal</creatorcontrib><creatorcontrib>Steinmann, Myriam</creatorcontrib><creatorcontrib>Do, Kim Q</creatorcontrib><creatorcontrib>Magistretti, Pierre J</creatorcontrib><creatorcontrib>Halfon, Olivier</creatorcontrib><creatorcontrib>Cardinaux, Jean-René</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovács, Krisztián A</au><au>Steullet, Pascal</au><au>Steinmann, Myriam</au><au>Do, Kim Q</au><au>Magistretti, Pierre J</au><au>Halfon, Olivier</au><au>Cardinaux, Jean-René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2007-03-13</date><risdate>2007</risdate><volume>104</volume><issue>11</issue><spage>4700</spage><epage>4705</epage><pages>4700-4705</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>17360587</pmid><doi>10.1073/pnas.0607524104</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (11), p.4700-4705 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_104_11_4700 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Active Transport, Cell Nucleus Animals Binding sites Biochemistry Biological Sciences Brain Calcineurin - metabolism Calcium Cloning Coincidence Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Genes Hippocampus - metabolism Long term potentiation Male Memory Mice Neurons Neurons - metabolism Phosphorylation Plasmids Protein synthesis Rats Recombinant proteins RNA, Messenger - metabolism Synapses Torcs Trans-Activators - physiology Transcription Factors - metabolism Transcription Factors - physiology |
| title | TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A21%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pnas_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TORC1%20is%20a%20calcium-%20and%20cAMP-sensitive%20coincidence%20detector%20involved%20in%20hippocampal%20long-term%20synaptic%20plasticity&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Kov%C3%A1cs,%20Kriszti%C3%A1n%20A&rft.date=2007-03-13&rft.volume=104&rft.issue=11&rft.spage=4700&rft.epage=4705&rft.pages=4700-4705&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0607524104&rft_dat=%3Cjstor_pnas_%3E25426896%3C/jstor_pnas_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201396200&rft_id=info:pmid/17360587&rft_jstor_id=25426896&rfr_iscdi=true |