Effective Expansion of Alloantigen-Specific Foxp3⁺ CD25⁺ CD4⁺ Regulatory T Cells by Dendritic Cells during the Mixed Leukocyte Reaction

Thymic-derived CD25⁺ CD4⁺ T regulatory cells (Tregs) suppress immune responses, including transplantation. Here we evaluated the ability of dendritic cells (DCs) to expand alloantigen-specific Tregs in the mixed leukocyte reaction (MLR) that develops from polyclonal populations of T cells. The allog...

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