Relevance and Safety of Telomerase for Human Tissue Engineering

Tissue engineering holds the promise of replacing damaged or diseased tissues and organs. The use of autologous donor cells is often not feasible because of the limited replicative lifespan of cells, particularly those derived from elderly patients. Proliferative arrest can be overcome by the ectopi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-02, Vol.103 (8), p.2500-2505
Hauptverfasser:	Klinger, Rebecca Y., Blum, Juliana L., Hearn, Bevin, Lebow, Benjamin, Niklason, Laura E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blood Vessels - cytology Blood Vessels - enzymology Blood Vessels - physiology Cell culture techniques Cell Culture Techniques - methods Cell growth Cell Transformation, Neoplastic Cellular senescence Chromosome Aberrations Cultured cells DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endothelial cells Humans Karyotype Mesenchymal stem cells Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - physiology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - physiology Older adults Retroviridae - genetics Telomerase - genetics Telomerase - metabolism Telomere - enzymology Telomere - genetics Tissue engineering Tissue Engineering - methods Tissue Engineering Special Feature Transfection Tumors
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