Role of β-Arrestin 1 in the Metastatic Progression of Colorectal Cancer

G protein-coupled receptor ligand-dependent transactivation of growth factor receptors has been implicated in human cancer cell proliferation, migration, and cell survival. For example, prostaglandin E₂ (PGE₂)-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-01, Vol.103 (5), p.1492-1497
Hauptverfasser:	Buchanan, F. Gregory, Gorden, D. Lee, Matta, Pranathi, Shi, Qiong, Matrisian, Lynn M., DuBois, Raymond N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Arrestins - metabolism Arrestins - physiology beta-Arrestin 1 beta-Arrestins Biological Sciences Blotting, Western Cell adhesion & migration Cell Line, Tumor Cell Membrane - metabolism Cell Movement Collagen - chemistry Colorectal cancer Colorectal neoplasms Colorectal Neoplasms - pathology Cytosol Cytosol - metabolism Densitometry Dinoprostone - metabolism Disease Progression Drug Combinations Humans Immunohistochemistry Immunoprecipitation Laminin - chemistry Liver Medical research Metastasis Microscopy, Fluorescence Models, Biological Neoplasm Metastasis Phosphorylation Phosphotyrosine - chemistry Prostaglandins Protein-Tyrosine Kinases - metabolism Proteins Proteoglycans - chemistry Receptor, Epidermal Growth Factor - metabolism Receptors Receptors, Prostaglandin E - metabolism Receptors, Prostaglandin E, EP4 Subtype Signal Transduction src-Family Kinases Time Factors Transactivation Transcriptional Activation Tumors
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