Androgen Receptor as a Licensing Factor for DNA Replication in Androgen-Sensitive Prostate Cancer Cells

Androgen receptor (AR) protein expression and function are critical for survival and proliferation of androgen-sensitive (AS) prostate cancer cells. Besides its ability to function as a transcription factor, experimental observations suggest that AR becomes a licensing factor for DNA replication in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (41), p.15085-15090
Hauptverfasser:	Litvinov, Ivan V., Griend, Donald J. Vander, Antony, Lizamma, Dalrymple, Susan, De Marzo, Angelo M., Drake, Charles G., Isaacs, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Receptor Antagonists Androgens Animals Antibodies B lymphocytes Biological Sciences Cell cycle Cell Cycle - genetics Cell division Cell growth Cell Line, Tumor Cell lines Deoxyribonucleic acid DNA DNA replication DNA Replication - genetics Humans Male Mice Mice, Nude Mitosis Neoplasm Transplantation Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - biosynthesis Receptors, Androgen - physiology Stromal cells Studies Tumor Cells, Cultured
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