Three Restricted Forms of Epstein-Barr Virus Latency Counteracting Apoptosis in C-Myc-Expressing Burkitt Lymphoma Cells

Epstein-Barr virus (EBV), a human herpesvirus, transforms B cell growth in vitro through expressing six virus-coded Epstein-Barr nuclear antigens (EBNAs) and two latent membrane proteins (LMPs). In many EBV-associated tumors, however, viral antigen expression is more restricted, and the aetiological...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (40), p.14935-14940
Hauptverfasser:	Kelly, Gemma L., Milner, Anne E., Baldwin, Gouri S., Bell, Andrew I., Rickinson, Alan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis B lymphocytes Biological Sciences Burkitt Lymphoma - metabolism Burkitt Lymphoma - pathology Cancer Cell growth Cell Line, Tumor Cell lines Child Chromosomes Clone Cells Epstein Barr virus infections Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens - genetics Epstein-Barr Virus Nuclear Antigens - metabolism Female Gene expression Gene Expression Regulation, Viral Genome, Viral - genetics Genomes Herpesvirus 4, Human - physiology Human herpesvirus Humans Infections Proto-Oncogene Proteins c-myc - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic Tumor cell line Tumor Cells, Cultured Tumors Viral Matrix Proteins - metabolism Viral Proteins - metabolism Virus Latency - physiology Viruses
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