ITK and IL-15 Support Two Distinct Subsets of CD8⁺ T Cells

CD8⁺ T cells are commonly divided into naïve $CD44^{Io}CD122^{Io}$ and "memory phenotype" $CD44^{hi}CD122^{hi}$ cells. Here we show data suggesting that these two cell populations represent independent CD8⁺ T cell subsets. Whereas $IL-15^{-/-}$ mice lack $CD44^{hi}CD122^{hi}$ CD8⁺ T cells,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-08, Vol.103 (32), p.12075-12080
Hauptverfasser:	Dubois, Sigrid, Waldmann, Thomas A., Müller, Jürgen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Gene Deletion Hyaluronan Receptors - biosynthesis Immunity Interleukin-15 - metabolism Interleukin-15 - physiology Ligands Lymphocyte Subsets Mice Mice, Inbred C57BL Mice, Transgenic Natural killer T cells Phenotype Phenotypes Protein-Tyrosine Kinases - physiology Receptors Receptors, Interleukin-2 - biosynthesis T cell antigen receptors T lymphocytes Thymocytes Thymus Gland - cytology Thymus Gland - metabolism
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