Nonsteroidal Anti-Inflammatory Drugs Repress β-Secretase Gene Promoter Activity by the Activation of PPARγ

Epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome proliferator-activated receptor-γ (PPARγ), which is a nuclear transcriptional regulator. Here we show that PPARγ deplet...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-01, Vol.103 (2), p.443-448
Hauptverfasser:	Sastre, Magdalena, Dewachter, Ilse, Rossner, Steffen, Bogdanovic, Nenad, Rosen, Evan, Borghgraef, Peter, Evert, Bernd O., Dumitrescu-Ozimek, Lucia, Thal, Dietmar R., Landreth, Gary, Walter, Jochen, Klockgether, Thomas, van Leuven, Fred, Heneka, Michael T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Biological Sciences Complementary DNA Cytokines Genes HEK293 cells Messenger RNA Neurons Quantification Small interfering RNA Transgenic animals
Online-Zugang:	Volltext
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