Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous mouse models have been generated. In both AD patients and mouse models, there is increasing evidence that neuronal dysfunction occurs before the accumulation of β-amyloid (Aβ)-containing plaques and neurodeg...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-03, Vol.103 (13), p.5161-5166
Hauptverfasser:	Jacobsen, J. Steven, Wu, Chi-Cheng, Redwine, Jeffrey M., Comery, Thomas A., Arias, Robert, Bowlby, Mark, Martone, Robert, Morrison, John H., Pangalos, Menelas N., Reinhart, Peter H., Bloom, Floyd E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloids Animal behavior Animals Astrocytes Behavior, Animal - physiology Behavioral neuroscience Biological Sciences Brain - metabolism Chlorofluorocarbons Cognition & reasoning Density Disease Models, Animal Entorhinal cortex Fear Hippocampus Long term potentiation Memory Memory disorders Mice Mice, Transgenic Neurology Neurons Organ Size Rodents Spine - pathology Synapses - metabolism Synapses - pathology Synaptophysin - metabolism Time Factors Transgenic animals
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!