BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes

Cell membranes isolated from brain tissues, obtained surgically from six patients afflicted with drug-resistant temporal lobe epilepsy and from one nonepileptic patient afflicted with a cerebral oligodendroglioma, were injected into frog oocytes. By using this approach, the oocytes acquire human GAB...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-02, Vol.102 (5), p.1667-1672
Hauptverfasser:	Palma, E, Torchia, G, Limatola, C, Trettel, F, Arcella, A, Cantore, G, Di Gennaro, G, Manfredi, M, Esposito, V, Quarato, P P, Miledi, R, Eusebi, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain Brain Tissue Transplantation - physiology Brain-Derived Neurotrophic Factor - pharmacology Drug resistance Enzyme Inhibitors - pharmacology Epilepsy Epilepsy - physiopathology Female gamma-Aminobutyric Acid - pharmacology Humans Medical research Membrane Potentials - drug effects Membrane Potentials - physiology Membranes Oocytes - drug effects Oocytes - physiology Patch-Clamp Techniques Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Staurosporine - pharmacology Transplantation, Heterologous - physiology Type C Phospholipases - antagonists & inhibitors Xenopus
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