EsxA and EsxB Are Secreted by an ESAT-6-Like System That Is Required for the Pathogenesis of Staphylococcus aureus Infections

Mycobacterium tuberculosis secretes ESAT-6, a virulence factor that triggers cell-mediated immune responses and IFN-γ production during tuberculosis. ESAT-6 is transported across the bacterial envelope by a specialized secretion system with a FSD (FtsK-SpoIIIE domain) membrane protein. Although the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-01, Vol.102 (4), p.1169-1174
Hauptverfasser:	Burts, Monica L., Williams, Wade A., DeBord, Kristin, Missiakas, Dominique M., Haselkorn, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess - etiology Abscesses Amino Acid Sequence Animals Antigens, Bacterial - analysis Antigens, Bacterial - physiology Bacteria Bacterial Proteins Biological Sciences Cell walls Codons Cultured cells Female Genes Infections Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Mutation Mycobacterium tuberculosis Pathogenesis Phenotype Proteins Secretion Staphylococcal Infections - etiology Staphylococcus Staphylococcus aureus Staphylococcus aureus - pathogenicity Virulence Factors - physiology
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