Formation of Apoptosome Is Initiated by Cytochrome c-Induced dATP Hydrolysis and Subsequent Nucleotide Exchange on Apaf-1

Apoptosis in metazoans is executed by a group of intracellular proteases named caspases. One of the caspase-activating pathways in mammals is initiated by the release of cytochrome c from mitochondria to cytosol, where it binds to Apaf-1 to form a procaspase-9-activating heptameric protein complex n...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (49), p.17545-17550
Hauptverfasser:	Kim, Hyun-Eui, Du, Fenghe, Fang, Min, Wang, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptotic Protease-Activating Factor 1 Biological Sciences Caspase 3 Caspases - metabolism Complementary DNA Cytochromes Cytochromes c - metabolism Deoxyadenine Nucleotides - metabolism Enzyme Activation Horses Hydrolysis Intracellular Membranes - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Liquids Mitochondria Nucleotides Organelles - metabolism Phosphates Plasmids Proteins Proteins - genetics Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!