Negative Regulation of Toll-like-Receptor Signaling by IRF-4

The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of down-stream target genes, wherein the TLR-interacting adaptor molecule MyD88 recruits various signaling molecule...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (44), p.15989-15994
Hauptverfasser:	Negishi, Hideo, Ohba, Yusuke, Yanai, Hideyuki, Takaoka, Akinori, Honma, Kiri, Yui, Katsuyuki, Matsuyama, Toshifumi, Taniguchi, Tadatsugu, Honda, Kenya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Antigens, Differentiation - metabolism Biological Sciences Bone marrow cells Cytokines Cytokines - blood Delta cells Gene Expression Regulation Genes HEK293 cells Hypersensitivity Immune system Immunology Inductive reasoning Interferon Regulatory Factor-7 - metabolism Interferon Regulatory Factors - genetics Interferon Regulatory Factors - immunology Interferon Regulatory Factors - metabolism Interferon Regulatory Factors - physiology Macrophages Macrophages, Peritoneal - immunology Messenger RNA Mice Mice, Knockout Molecules Myeloid Differentiation Factor 88 Peritoneal macrophages Receptors, Immunologic - metabolism Rodents Signal Transduction Toll-Like Receptors - immunology Toll-Like Receptors - metabolism
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