Quantitative High-Throughput Analysis of DNA Methylation Patterns by Base-Specific Cleavage and Mass Spectrometry

Methylation is one of the major epigenetic processes pivotal to our understanding of carcinogenesis. It is now widely accepted that there is a relationship between DNA methylation, chromatin structure, and human malignancies. DNA methylation is potentially an important clinical marker in cancer mole...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (44), p.15785-15790
Hauptverfasser:	Mathias Ehrich, Nelson, Matthew R., Stanssens, Patrick, Zabeau, Marc, Triantafillos Liloglou, George Xinarianos, Cantor, Charles R., John K. Field, van den Boom, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological Sciences Carcinogenesis Cluster Analysis Deoxyribonucleic acid Diagnostic Techniques and Procedures DNA DNA Methylation Gene amplification Genetics Genomics Genomics - methods Histopathology Humans Lung cancer Lung neoplasms Lung Neoplasms - classification Lung Neoplasms - pathology Mass spectrometry Mass spectroscopy Methylation Neoplasms - diagnosis Nucleotides Polymerase chain reaction Polymerase Chain Reaction - methods Promoter regions Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sulfites Tissue samples Tumors
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