Sequence Survey of Receptor Tyrosine Kinases Reveals Mutations in Glioblastomas

It is now clear that tyrosine kinases represent attractive targets for therapeutic intervention in cancer. Recent advances in DNA sequencing technology now provide the opportunity to survey mutational changes in cancer in a high-throughput and comprehensive manner. Here we report on the sequence ana...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-10, Vol.102 (40), p.14344-14349
Hauptverfasser:	Rand, Vikki, Huang, Jiaqi, Stockwell, Tim, Ferriera, Steve, Buzko, Oleksandr, Levy, Samuel, Busam, Dana, Li, Kelvin, Edwards, Jennifer B., Eberhart, Charles, Murphy, Kathleen M., Tsiamouri, Alexia, Beeson, Karen, Andrew J. G. Simpson, Venter, J. Craig, Riggins, Gregory J., Strausberg, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Base Sequence Biological Sciences Brain Neoplasms - genetics Cancer Child DNA Evolution, Molecular Exons Female Fibroblast growth factor receptors Genetic mutation Genomics Genomics - methods Glioblastoma Glioblastoma - genetics Humans Male Models, Genetic Models, Molecular Molecular Sequence Data Mutation - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Platelet-Derived Growth Factor alpha - genetics Receptors Sequence Analysis, DNA Sequencing Tumors
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