Pathophysiological Role of Toll-Like Receptor 5 Engagement by Bacterial Flagellin in Colonic Inflammation

Commensal and enteroinvasive microbes in the human gut release bacterial flagellin, a specific microbial ligand of Toll-like receptor 5 (TLR5). However, the pathophysiological role of bacterial flagellin in gastrointestinal inflammation has not been determined. Here we evaluated the role of bacteria...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-09, Vol.102 (38), p.13610-13615
Hauptverfasser:	Rhee, Sang Hoon, Im, Eunok, Riegler, Martin, Kokkotou, Efi, Michael O' Brien, Pothoulakis, Charalabos, Dinarello, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Apoptosis - drug effects Apoptosis - immunology Bacteria Biological Sciences Chemokines - immunology Colitis Colitis - chemically induced Colitis - immunology Colitis - pathology Colon Colon - pathology Colon - physiopathology Commensals Cytokines Epithelium Flagellin - immunology Flagellin - pharmacology Humans Inflammation Inflammation - immunology Inflammation - pathology Inflammatory bowel diseases Interleukin-6 - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Keratinocytes - immunology Keratinocytes - pathology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Male MAP Kinase Kinase 1 - immunology MAP Kinase Kinase 2 - immunology Membrane Glycoproteins - agonists Membrane Glycoproteins - immunology Mice Mucosa Pathology Peptidoglycan - immunology Peptidoglycan - pharmacology Receptors, Cell Surface - agonists Receptors, Cell Surface - immunology Signal Transduction - drug effects Signal Transduction - immunology Teichoic Acids - immunology Teichoic Acids - pharmacology Tissue Culture Techniques Toll-Like Receptor 2 Toll-Like Receptor 5 Toll-Like Receptors Tumor Necrosis Factor-alpha - immunology
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