Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila

Cooperative interactions by DNA-binding proteins have been implicated in cell-fate decisions in a variety of organisms. To date, however, there are few examples in which the importance of such interactions has been explicitly tested in vivo. Here, we tested the importance of cooperative DNA binding...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-09, Vol.102 (37), p.13176-13181
Hauptverfasser:	Lebrecht, D, Foehr, M, Smith, E, Lopes, F.J.P, Vanario-Alonso, C.E, Reinitz, J, Burz, D.S, Hanes, S.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Bicoid protein binding capacity Binding sites Biological Sciences Body Patterning Cooperation Deoxyribonucleic acid DNA DNA-binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Drosophila Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - growth & development Drosophila Proteins - genetics Drosophila Proteins - physiology Embryo, Nonmammalian - physiology embryogenesis Embryos Gene expression Gene Expression Regulation, Developmental Genes Genetic mutation Head - growth & development Homeodomain Proteins - genetics Homeodomain Proteins - physiology Insects messenger RNA mutants Mutation Phenotypes Protein Binding protein-protein interactions Proteins Thorax - growth & development Trans-Activators - genetics Trans-Activators - physiology transcription (genetics) Transcription Factors - genetics Transcription, Genetic Transgenes Yeasts
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