The Voltage-Gated Potassium Channel Kv1.3 Is Highly Expressed on Inflammatory Infiltrates in Multiple Sclerosis Brain

Multiple Sclerosis (MS) is characterized by central nervous system perivenular and parenchymal mononuclear cell infiltrates consisting of activated T cells and macrophages. We recently demonstrated that elevated expression of the voltage-gated potassium channel, Kv1.3, is a functional marker of acti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-08, Vol.102 (31), p.11094-11099
Hauptverfasser:	Rus, Horea, Pardo, Carlos A., Hu, Lina, Darrah, Erika, Cudrici, Cornelia, Niculescu, Teodora, Niculescu, Florin, Mullen, Katharine M., Allie, Rameeza, Guo, Liping, Wulff, Heike, Beeton, Christine, Susan I. V. Judge, Kerr, Douglas A., Knaus, Hans-Gunther, Chandy, K. George, Calabresi, Peter A., Latorre, Ramon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antagonist drugs Antibodies Biological Sciences Blood Brain Case-Control Studies Female Gray matter Humans Immunohistochemistry Immunologic Memory In Vitro Techniques Inflammation - immunology Inflammation - metabolism Inflammation - pathology Kv1.3 Potassium Channel Lesions Lymphocytes Macrophages Male Middle Aged Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neurology Phenotypes Potassium Channels, Voltage-Gated - metabolism Receptors, CCR7 Receptors, Chemokine - metabolism Signal transduction T lymphocytes T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism White matter
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