The Evolution of Human Anti-Double-Stranded DNA Autoantibodies

It has been proposed that the anti-double-stranded DNA (dsDNA) response in patients with systemic lupus erythematosus (SLE) is antigen driven and that DNA or nucleosomes select anti-DNA reactive, somatically mutated B cells. We have used site-directed mutagenesis to systematically revert the somatic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-06, Vol.102 (26), p.9258-9263
Hauptverfasser:	Wellmann, Ute, Letz, Miriam, Herrmann, Martin, Angermüller, Sieglinde, Kalden, Joachim R., Winkler, Thomas H., Weigert, Martin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies Antibodies - chemistry Antibodies, Monoclonal - chemistry Antigens Antigens - chemistry Apoptosis Autoantibodies Autoantibodies - chemistry B lymphocytes Biological Evolution Biological Sciences Deoxyribonucleic acid DNA DNA - chemistry DNA - immunology DNA, Single-Stranded - chemistry Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Evolution Flow Cytometry Genetic mutation Germ cells Humans Immunoglobulin G - chemistry Jurkat Cells Kinetics Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Molecular Sequence Data Mutagenesis, Site-Directed Mutation Nucleosomes Nucleosomes - metabolism Phosphatidylserines - chemistry Protein Binding Reactivity Somatic mutation Surface Plasmon Resonance
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