Ca2+-Regulated Structural Changes in Troponin

Troponin senses Ca2+to regulate contraction in striated muscle. Structures of skeletal muscle troponin composed of TnC (the sensor), TnI (the regulator), and TnT (the link to the muscle thin filament) have been determined. The structure of troponin in the Ca2+-activated state features a nearly twofo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-04, Vol.102 (14), p.5038-5043
Hauptverfasser:	Vinogradova, Maia V., Stone, Deborah B., Malanina, Galina G., Karatzaferi, Christina, Cooke, Roger, Mendelson, Robert A., Fletterick, Robert J., Cohen, Carolyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amino acids Binding sites Biochemistry Biological Sciences Biophysics Calcium Crystal structure Crystals Detergents Drug regulation Molecules Muscular system Sensors Skeletal muscle
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