Transgenic mice expressing a soluble form of porcine nectin-1/herpesvirus entry mediator C as a model for pseudorabies-resistant livestock

An approach to genetically engineered resistance to pseudorabies virus (PRV) infection was examined by using a transgene encoding a soluble form of nectin-1, also known as herpesvirus entry mediator C. Nectin-1 is an alpha-herpesvirus receptor that binds to virion glycoprotein D. Nectin-1 mediates e...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-11, Vol.101 (46), p.16150-16155
Hauptverfasser:	Ono, E, Amagai, K, Taharaguchi, S, Tomioka, Y, Yoshino, S, Watanabe, Y, Cherel, P, Houdebine, L.M, Adam, M, Eloit, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Aujeszky disease Base Sequence Biological Sciences Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - genetics Cell Adhesion Molecules - physiology Cellular Biology disease resistance DNA, Viral - genetics DNA, Viral - isolation & purification Fibroblasts Gene expression gene transfer Genetic engineering genetic resistance Herpes simplex virus Herpesviridae - pathogenicity Herpesvirus Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - isolation & purification Herpesvirus 1, Suid - pathogenicity Human herpesvirus 1 Humans Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - metabolism Immunoglobulin G - genetics Immunoglobulin G - metabolism Infections Lethal dose 50 Life Sciences Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological nectin-1 Nectins Polymerase Chain Reaction Pseudorabies - immunology Pseudorabies - prevention & control Pseudorabies - virology Pseudorabies virus receptors Receptors, Virus - chemistry Receptors, Virus - genetics Receptors, Virus - physiology Recombinant Proteins - genetics Recombinant Proteins - metabolism Rodents Solubility soluble receptors Suid herpesvirus 1 Sus scrofa swine Transgenes Transgenic animals Virology Viruses
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