Isolation of Mycobacterium tuberculosis Mutants Defective in the Arrest of Phagosome Maturation

Mycobacterium tuberculosis resides within the phagocytes of its host. It ensures its continued survival through arresting the normal maturation of its phagosome, which is retained within the early endosomal system of the macrophage. Although individual bacterial components have been shown to modulat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-09, Vol.101 (37), p.13642-13647
Hauptverfasser:	Pethe, Kevin, Swenson, Dana L., Alonso, Sylvie, Anderson, Jennifer, Wang, Carren, Russell, David G., Mekalanos, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Bacteria Biological Sciences Colloids - chemistry Genetic screening Genetics Genotype Gold - chemistry Gold - pharmacology Hydrogen-Ion Concentration Infections Macrophages Macrophages - cytology Macrophages - microbiology Macrophages - ultrastructure Microbiology Microscopy, Electron Mutation Mutation - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - cytology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - ultrastructure Phagosomes Phagosomes - genetics Phagosomes - physiology Phagosomes - ultrastructure Phenotype Phenotypes Spectrometry, Fluorescence Tuberculosis Vacuoles
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