β-Adrenergic Modulation of Emotional Memory-Evoked Human Amygdala and Hippocampal Responses
Human emotional experience is typically associated with enhanced episodic memory. We have used functional magnetic resonance imaging to demonstrate that successful encoding of emotional, compared to neutral, verbal stimuli evokes increased human amygdala responses. Items that evoke amygdala activati...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (31), p.11454-11458 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Strange, B. A. Dolan, R. J. McGaugh, James L. |
| description | Human emotional experience is typically associated with enhanced episodic memory. We have used functional magnetic resonance imaging to demonstrate that successful encoding of emotional, compared to neutral, verbal stimuli evokes increased human amygdala responses. Items that evoke amygdala activation at encoding evoke greater hippocampal responses at retrieval compared to neutral items. Administration of the β-adrenergic antagonist propranolol at encoding abolishes the enhanced amygdala encoding and hippocampal retrieval effects, despite propranolol being no longer present at retrieval. Thus, memory-related amygdala responses at encoding and hippocampal responses at recognition for emotional items depend on β-adrenergic engagement at encoding. Our results suggest that human emotional memory is associated with a β-adrenergic-dependent modulation of amygdala-hippocampal interactions. |
| doi_str_mv | 10.1073/pnas.0404282101 |
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Our results suggest that human emotional memory is associated with a β-adrenergic-dependent modulation of amygdala-hippocampal interactions.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0404282101</identifier><identifier>PMID: 15269349</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adrenergic beta-Antagonists - administration & dosage ; Adult ; Amygdala ; Amygdala - physiology ; Behavioral neuroscience ; Biological Sciences ; Brain ; Drug interactions ; Emotional expression ; Emotions ; Emotions - drug effects ; Emotions - physiology ; Female ; Hippocampus ; Hippocampus - physiology ; Humans ; Image contrast ; Magnetic Resonance Imaging ; Male ; Memory ; Memory recall ; Neurology ; Nouns ; Placebos ; Propranolol - administration & dosage ; Receptors, Adrenergic, beta - metabolism ; Recognition, Psychology - drug effects ; Recognition, Psychology - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (31), p.11454-11458</ispartof><rights>Copyright 1993/2004 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Aug 3, 2004</rights><rights>Copyright © 2004, The National Academy of Sciences 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-beea8859dbf6fababe5eb8911f511574d8091242e064a19bff79f80fe907b6e13</citedby><cites>FETCH-LOGICAL-c526t-beea8859dbf6fababe5eb8911f511574d8091242e064a19bff79f80fe907b6e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/101/31.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3372797$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3372797$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15269349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strange, B. A.</creatorcontrib><creatorcontrib>Dolan, R. J.</creatorcontrib><creatorcontrib>McGaugh, James L.</creatorcontrib><title>β-Adrenergic Modulation of Emotional Memory-Evoked Human Amygdala and Hippocampal Responses</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Human emotional experience is typically associated with enhanced episodic memory. We have used functional magnetic resonance imaging to demonstrate that successful encoding of emotional, compared to neutral, verbal stimuli evokes increased human amygdala responses. Items that evoke amygdala activation at encoding evoke greater hippocampal responses at retrieval compared to neutral items. Administration of the β-adrenergic antagonist propranolol at encoding abolishes the enhanced amygdala encoding and hippocampal retrieval effects, despite propranolol being no longer present at retrieval. Thus, memory-related amygdala responses at encoding and hippocampal responses at recognition for emotional items depend on β-adrenergic engagement at encoding. Our results suggest that human emotional memory is associated with a β-adrenergic-dependent modulation of amygdala-hippocampal interactions.</description><subject>Adrenergic beta-Antagonists - administration & dosage</subject><subject>Adult</subject><subject>Amygdala</subject><subject>Amygdala - physiology</subject><subject>Behavioral neuroscience</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Drug interactions</subject><subject>Emotional expression</subject><subject>Emotions</subject><subject>Emotions - drug effects</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - physiology</subject><subject>Humans</subject><subject>Image contrast</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory</subject><subject>Memory recall</subject><subject>Neurology</subject><subject>Nouns</subject><subject>Placebos</subject><subject>Propranolol - administration & dosage</subject><subject>Receptors, Adrenergic, beta - metabolism</subject><subject>Recognition, Psychology - drug effects</subject><subject>Recognition, Psychology - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EotvCmQtCEQckDmlnHGdjHzisqoUitUJCcEOynGS8ZEni1E4q9m_1h_CbcLSrLnDh5JH9vafneYy9QDhHKLKLoTfhHAQILjkCPmILBIXpUih4zBYAvEil4OKEnYawBQCVS3jKTjDnS5UJtWDfft2nq9pTT37TVMmNq6fWjI3rE2eTdefm0bTJDXXO79L1nftBdXI1daZPVt1uU5vWJKaPV80wuMp0Q4Q_UxhcHyg8Y0-saQM9P5xn7Ov79ZfLq_T604ePl6vrtIo5xrQkMlLmqi7t0prSlJRTKRWizRHzQtQy_okLTrAUBlVpbaGsBEsKinJJmJ2xd3vfYSo7qivqR29aPfimM36nnWn03y99811v3J3OQXHOo_7NQe_d7URh1F0TKmpb05ObgsZCRlLJCL7-B9y6yccFBc0BeYycz24Xe6jyLgRP9iEIgp5b03Nr-thaVLz6M_-RP9QUgbcHYFYe7VBnqBFFLrSd2nakn2Nkk_-wEXm5R7ZhdP6BybKCF6rIfgNTrLd8</recordid><startdate>20040803</startdate><enddate>20040803</enddate><creator>Strange, B. A.</creator><creator>Dolan, R. J.</creator><creator>McGaugh, James L.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20040803</creationdate><title>β-Adrenergic Modulation of Emotional Memory-Evoked Human Amygdala and Hippocampal Responses</title><author>Strange, B. A. ; Dolan, R. J. ; McGaugh, James L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-beea8859dbf6fababe5eb8911f511574d8091242e064a19bff79f80fe907b6e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenergic beta-Antagonists - administration & dosage</topic><topic>Adult</topic><topic>Amygdala</topic><topic>Amygdala - physiology</topic><topic>Behavioral neuroscience</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>Drug interactions</topic><topic>Emotional expression</topic><topic>Emotions</topic><topic>Emotions - drug effects</topic><topic>Emotions - physiology</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Image contrast</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory</topic><topic>Memory recall</topic><topic>Neurology</topic><topic>Nouns</topic><topic>Placebos</topic><topic>Propranolol - administration & dosage</topic><topic>Receptors, Adrenergic, beta - metabolism</topic><topic>Recognition, Psychology - drug effects</topic><topic>Recognition, Psychology - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strange, B. 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Administration of the β-adrenergic antagonist propranolol at encoding abolishes the enhanced amygdala encoding and hippocampal retrieval effects, despite propranolol being no longer present at retrieval. Thus, memory-related amygdala responses at encoding and hippocampal responses at recognition for emotional items depend on β-adrenergic engagement at encoding. Our results suggest that human emotional memory is associated with a β-adrenergic-dependent modulation of amygdala-hippocampal interactions.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>15269349</pmid><doi>10.1073/pnas.0404282101</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic beta-Antagonists - administration & dosage Adult Amygdala Amygdala - physiology Behavioral neuroscience Biological Sciences Brain Drug interactions Emotional expression Emotions Emotions - drug effects Emotions - physiology Female Hippocampus Hippocampus - physiology Humans Image contrast Magnetic Resonance Imaging Male Memory Memory recall Neurology Nouns Placebos Propranolol - administration & dosage Receptors, Adrenergic, beta - metabolism Recognition, Psychology - drug effects Recognition, Psychology - physiology |
| title | β-Adrenergic Modulation of Emotional Memory-Evoked Human Amygdala and Hippocampal Responses |
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