Watching Proteins Fold One Molecule at a Time

Recent theoretical work suggests that protein folding involves an ensemble of pathways on a rugged energy landscape. We provide direct evidence for heterogeneous folding pathways from single-molecule studies, facilitated by a recently developed immobilization technique. Individual fluorophore-labele...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-03, Vol.100 (6), p.3197-3202
Hauptverfasser:	Rhoades, Elizabeth, Gussakovsky, Eugene, Haran, Gilad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - chemistry Adenylate Kinase - genetics Biological Sciences Energy Energy transfer Enzymes, Immobilized Escherichia coli - enzymology Escherichia coli - genetics Fluorescence Fluorescence Resonance Energy Transfer Fluorescent Dyes Glass Kinetics Laser beams Lipids Models, Molecular Molecules Mutagenesis, Insertional Physical Sciences Polarized light Protein Conformation Protein Folding Proteins Thermodynamics Trajectories
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