Identification of the Coupling between Skeletal Muscle Store-Operated Ca2+Entry and the Inositol Trisphosphate Receptor

Examination of store-operated Ca2+entry (SOC) in single, mechanically skinned skeletal muscle cells by confocal microscopy shows that the inositol 1,4,5-trisphosphate (IP3) receptor acts as a sarcoplasmic reticulum [ Ca2+] sensor and mediates SOC by physical coupling without playing a key role in Ca...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-03, Vol.100 (5), p.2941-2944
Hauptverfasser:	Launikonis, Bradley S., Barnes, Melissa, Stephenson, D. George
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anura Biological Sciences Calcium Calcium - metabolism Cell Membrane - metabolism Cell membranes Cytoplasm - metabolism Dose-Response Relationship, Drug Electrophysiology Fibrinolytic Agents - pharmacology Fluorescence Heparin Heparin - pharmacology Homeostasis Inositol 1,4,5-Trisphosphate - metabolism Inositols Microscopy, Confocal Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Muscular system Receptors Sarcoplasmic Reticulum - metabolism Sensors Skeletal muscle Skeletal system Statistical significance Time Factors
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