Induction of Colitis by a CD4+T Cell Clone Specific for a Bacterial Epitope

It is now well established that the intestinal flora plays an important role in the pathogenesis of inflammatory bowel disease (IBD). However, whether bacteria serve as the sole target of the immune response in this process or whether they act indirectly by triggering an anti-self response is still...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-12, Vol.100 (26), p.15830-15835
Hauptverfasser:	Kullberg, Marika C., Andersen, John F., Gorelick, Peter L., Caspar, Patricia, Suerbaum, Sebastian, Fox, James G., Cheever, Allen W., Jankovic, Dragana, Sher, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Bacterial - immunology Bacteria Bacterial Infections - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology Biological Sciences CD4-Positive T-Lymphocytes - immunology Cell lines Cells, Cultured Clone Cells Cloning Colitis Cytokines - analysis DNA-Binding Proteins - deficiency DNA-Binding Proteins - immunology Epitopes Epitopes - immunology Helicobacter Helicobacter - genetics Helicobacter - immunology Helicobacter Infections - immunology Immunology Inflammation Inflammatory bowel diseases Interleukin-10 - deficiency Interleukin-10 - immunology Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Sequence Alignment T cell antigen receptors T lymphocytes
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