Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone

The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone that mediates developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) by the action of a P450 monooxygenase that hydroxylates E at carbon 20. The gene coding for this key enzyme of ecdysteroid...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-11, Vol.100 (24), p.13773-13778
Hauptverfasser:	Petryk, A, Warren, J.T, Marques, G, Jarcho, M.P, Gilbert, L.I, Kahler, J, Parvy, J.P, Li, Y, Dauphin-Villemant, C, O'Connor, M.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Base Sequence Biochemistry Biological Sciences biosynthesis Body tissues Cell Line Cloning, Molecular complementary DNA cytochrome P-450 disembodied gene DNA, Complementary - genetics Drosophila Drosophila - genetics Drosophila - growth & development Drosophila - metabolism Drosophila melanogaster E-20-monooxygenase ecdysone Ecdysone - metabolism Ecdysteroids ecdysterone Ecdysterone - metabolism embryo (animal) Embryos enzyme activity Enzymes Fat body Female Gene Expression Genes, Insect Hormones Hydroxylation Insect biochemistry Insects Larvae messenger RNA Molecular Sequence Data Mutation nucleotide sequences Ovaries Phenotype Salivary glands Shade protein shadow gene shd gene Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism Subcellular Fractions - metabolism Transfection
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