Disrupted-in-Schizophrenia-1 (DISC-1): Mutant Truncation Prevents Binding to NudE-like (NUDEL) and Inhibits Neurite Outgrowth

Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. We have cloned and characterized rodent DISC-1. DISC-1 expression displays pronounced developmental regulation with the highest le...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-01, Vol.100 (1), p.289-294
Hauptverfasser:	Ozeki, Yuji, Tomoda, Toshifumi, Kleiderlein, John, Kamiya, Atsushi, Bord, Lyuda, Fujii, Kumiko, Okawa, Masako, Yamada, Naoto, Hatten, Mary E., Snyder, Solomon H., Ross, Christopher A., Sawa, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological Sciences Cell lines Cloning, Molecular COS cells Cysteine Endopeptidases DNA Primers Exons Genes HeLa cells Humans Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurites Neurites - physiology Neurology Neurons PC12 cells Protein Binding Proteins Rats Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents Schizophrenia Sequence Deletion Serine Endopeptidases - metabolism Subcellular Fractions - metabolism
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