Stearoyl-CoA Desaturase 1 Deficiency Elevates Insulin-Signaling Components and Down-Regulates Protein-Tyrosine Phosphatase 1B in Muscle

We have shown previously that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased insulin sensitivity compared with control mice. Here we show that the SCD1-/-mice have increased insulin signaling in muscle. The basal tyrosine phosphorylation of the insulin...

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