Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

Epithelial-to-mesenchymal cell transition (EMT) is a basic process in embryonic development and cancer progression. The present study demonstrates involvement of glycosphingolipids (GSLs) in the EMT process by using normal murine mammary gland NMuMG, human normal bladder HCV29, and human mammary car...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-05, Vol.106 (18), p.7461-7466
Hauptverfasser:	Guan, Feng, Handa, Kazuko, Hakomori, Sen-itiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cadherins Cancer Cell adhesion Cell Line Cell lines Cell motility Cell Movement Cells Cultured cells Embryonic stem cells Enzyme Inhibitors - pharmacology Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - physiology G(M2) Ganglioside - pharmacology Gangliosides Gangliosides - pharmacology Genotype & phenotype Glucosyltransferases - antagonists & inhibitors Glycosphingolipids - metabolism Glycosphingolipids - physiology Humans Mesenchymal stem cells Mesoderm - cytology Mesoderm - drug effects Mesoderm - physiology Mice Molecules Propanolamines - pharmacology Pyrrolidines - pharmacology Rodents Studies Transforming Growth Factor beta - pharmacology
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