mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii

Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the para...

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Veröffentlicht in:	PloS one 2025-01, Vol.20 (1), p.e0316209
Hauptverfasser:	Kravets, Elisabeth, Poschmann, Gereon, Hänsch, Sebastian, Raba, Veronica, Weidtkamp-Peters, Stefanie, Degrandi, Daniel, Stühler, Kai, Pfeffer, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding proteins Biology and Life Sciences Cell growth Cloning Control CRISPR Defense mechanisms Fibroblasts Galectin-9 Galectins - immunology Galectins - metabolism Genetic modification GTP-Binding Proteins - genetics GTP-Binding Proteins - immunology GTP-Binding Proteins - metabolism Guanylate-binding protein Health aspects Host-Parasite Interactions - immunology Humans Immunity Infections Intracellular Medicine and Health Sciences Mice Parasites Parasitophorous vacuole Pathogens Penicillin Physiological aspects Proteins Protozoa Research and analysis methods Toxoplasma Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis - immunology Toxoplasmosis - parasitology Vacuoles - metabolism Vacuoles - parasitology
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