Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas
This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC). BioTrace utilizes a proprietary algorithm to analyze the temporo-spa...
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| Veröffentlicht in: | PloS one 2025-01, Vol.20 (1), p.e0317469 |
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| creator | Sato, Masaya Tateishi, Ryosuke Zohar, Yogev Sato, Jiro Watadani, Takeyuki Moriyama, Makoto Wake, Taijiro Nakagomi, Ryo Kinoshita, Mizuki Nishibatake Nakatsuka, Takuma Minami, Tatsuya Uchino, Koji Enooku, Kenichiro Nakagawa, Hayato Asaoka, Yoshinari Yamada, Ryo Even, Nitzan Amitai, Inbal Abu, Yossi Fujishiro, Mitsuhiro Koike, Kazuhiko |
| description | This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC).
BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing the ablation zones it predicted with those annotated by radiologists using contrast-enhanced computed tomography (CECT) 24 hours post-treatment, considered the gold standard. The study included 20 liver tumors.
The median tumor measurement along the major axis was 1.2 cm. The median Dice coefficient, Sensitivity, and Precision between BioTrace and CECT were 0.90, 0.91, and 0.91, respectively. The intraclass correlation showed excellent agreement in volume size between BioTrace and CECT findings (0.98).
BioTrace effectively generates an ablation damage prediction map based on real-time ultrasound imaging, accurately predicting the ablation zone as confirmed by 24-hour post-procedural CECT. This system has the potential to enhance the safety and efficacy of ablation procedures in clinical settings. |
| doi_str_mv | 10.1371/journal.pone.0317469 |
| format | Article |
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BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing the ablation zones it predicted with those annotated by radiologists using contrast-enhanced computed tomography (CECT) 24 hours post-treatment, considered the gold standard. The study included 20 liver tumors.
The median tumor measurement along the major axis was 1.2 cm. The median Dice coefficient, Sensitivity, and Precision between BioTrace and CECT were 0.90, 0.91, and 0.91, respectively. The intraclass correlation showed excellent agreement in volume size between BioTrace and CECT findings (0.98).
BioTrace effectively generates an ablation damage prediction map based on real-time ultrasound imaging, accurately predicting the ablation zone as confirmed by 24-hour post-procedural CECT. This system has the potential to enhance the safety and efficacy of ablation procedures in clinical settings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0317469</identifier><identifier>PMID: 39823502</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ablation ; Aged ; Algorithms ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - surgery ; Care and treatment ; Catheter Ablation - methods ; Computed tomography ; Computer programs ; Computer-assisted surgery ; Damage ; Evaluation ; Female ; Hepatocellular carcinoma ; Hepatoma ; Humans ; Image processing ; Image Processing, Computer-Assisted - methods ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - surgery ; Magnetic resonance imaging ; Male ; Medical imaging ; Methods ; Middle Aged ; Navigation systems ; Performance evaluation ; Predictions ; Radio frequency ; Radiofrequency ablation ; Radiofrequency Ablation - methods ; Real time ; Registration ; Retrospective Studies ; Software ; Temperature ; Thermal imaging ; Tomography ; Tomography, X-Ray Computed - methods ; Tumors ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Ultrasound imaging</subject><ispartof>PloS one, 2025-01, Vol.20 (1), p.e0317469</ispartof><rights>Copyright: © 2025 Sato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2025 Public Library of Science</rights><rights>2025 Sato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2025 Sato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3192-72392f1f7e5241aece1057eedd9ac43e70c19da610cb0b4a45189613596904353</cites><orcidid>0000-0002-2805-8226 ; 0000-0003-3021-2517 ; 0000-0002-4074-1140 ; 0000-0001-5423-9664</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0317469&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0317469$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2915,23845,27901,27902,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39823502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Masaya</creatorcontrib><creatorcontrib>Tateishi, Ryosuke</creatorcontrib><creatorcontrib>Zohar, Yogev</creatorcontrib><creatorcontrib>Sato, Jiro</creatorcontrib><creatorcontrib>Watadani, Takeyuki</creatorcontrib><creatorcontrib>Moriyama, Makoto</creatorcontrib><creatorcontrib>Wake, Taijiro</creatorcontrib><creatorcontrib>Nakagomi, Ryo</creatorcontrib><creatorcontrib>Kinoshita, Mizuki Nishibatake</creatorcontrib><creatorcontrib>Nakatsuka, Takuma</creatorcontrib><creatorcontrib>Minami, Tatsuya</creatorcontrib><creatorcontrib>Uchino, Koji</creatorcontrib><creatorcontrib>Enooku, Kenichiro</creatorcontrib><creatorcontrib>Nakagawa, Hayato</creatorcontrib><creatorcontrib>Asaoka, Yoshinari</creatorcontrib><creatorcontrib>Yamada, Ryo</creatorcontrib><creatorcontrib>Even, Nitzan</creatorcontrib><creatorcontrib>Amitai, Inbal</creatorcontrib><creatorcontrib>Abu, Yossi</creatorcontrib><creatorcontrib>Fujishiro, Mitsuhiro</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC).
BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing the ablation zones it predicted with those annotated by radiologists using contrast-enhanced computed tomography (CECT) 24 hours post-treatment, considered the gold standard. The study included 20 liver tumors.
The median tumor measurement along the major axis was 1.2 cm. The median Dice coefficient, Sensitivity, and Precision between BioTrace and CECT were 0.90, 0.91, and 0.91, respectively. The intraclass correlation showed excellent agreement in volume size between BioTrace and CECT findings (0.98).
BioTrace effectively generates an ablation damage prediction map based on real-time ultrasound imaging, accurately predicting the ablation zone as confirmed by 24-hour post-procedural CECT. This system has the potential to enhance the safety and efficacy of ablation procedures in clinical settings.</description><subject>Ablation</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Care and treatment</subject><subject>Catheter Ablation - methods</subject><subject>Computed tomography</subject><subject>Computer programs</subject><subject>Computer-assisted surgery</subject><subject>Damage</subject><subject>Evaluation</subject><subject>Female</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Image processing</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - surgery</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Navigation systems</subject><subject>Performance evaluation</subject><subject>Predictions</subject><subject>Radio frequency</subject><subject>Radiofrequency ablation</subject><subject>Radiofrequency Ablation - methods</subject><subject>Real time</subject><subject>Registration</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>Temperature</subject><subject>Thermal imaging</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Ultrasound imaging</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkttrFDEUxoMotl39D0QDQtGHWXOZWx5L8VIoFOrlNZzJnNmmZCdjMrO6-M-bdafSlT5IHhLC7_s4fOcj5AVnSy4r_u7WT6EHtxx8j0smeZWX6hE55kqKrBRMPr73PiInMd4yVsi6LJ-SI6lqIQsmjsmvaxyDjwOa0W6Q4gbcBKP1PfUdBdr7DTo6uTFA9FPfZg1EbKldw8r2KwppgG20kUbfjT8gIO18oEPA1ia_BARore8Cfp-wN1sKjdubJxTiM_KkAxfx-XwvyNcP77-cf8ourz5enJ9dZkZyJbJKSCU63lVYiJwDGuSsqBDbVoHJJVbMcNVCyZlpWJNDXvBalVwWqlQsl4VckFd738H5qOfcopa8KKtKqD_Em5kIPo0aR7220aBz0KOf9mjNBMvrhL7-B33YcKZW4FDbvvMpQbMz1WcpeiVrlbgFWT5ApdPi2pq0186m_wPB2wNBYkb8Oa5gilFffL7-f_bq2yF7eo-9QXDjTfRu2u0qHoL5HjSpNDFgp4eQyhC2mjO9q-VdGnpXSz3XMslezqFNzRrbv6K7Hsrf9aXd8Q</recordid><startdate>20250117</startdate><enddate>20250117</enddate><creator>Sato, Masaya</creator><creator>Tateishi, Ryosuke</creator><creator>Zohar, Yogev</creator><creator>Sato, Jiro</creator><creator>Watadani, Takeyuki</creator><creator>Moriyama, Makoto</creator><creator>Wake, Taijiro</creator><creator>Nakagomi, Ryo</creator><creator>Kinoshita, Mizuki Nishibatake</creator><creator>Nakatsuka, Takuma</creator><creator>Minami, Tatsuya</creator><creator>Uchino, Koji</creator><creator>Enooku, Kenichiro</creator><creator>Nakagawa, Hayato</creator><creator>Asaoka, Yoshinari</creator><creator>Yamada, Ryo</creator><creator>Even, Nitzan</creator><creator>Amitai, Inbal</creator><creator>Abu, Yossi</creator><creator>Fujishiro, Mitsuhiro</creator><creator>Koike, Kazuhiko</creator><general>Public Library of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2805-8226</orcidid><orcidid>https://orcid.org/0000-0003-3021-2517</orcidid><orcidid>https://orcid.org/0000-0002-4074-1140</orcidid><orcidid>https://orcid.org/0000-0001-5423-9664</orcidid></search><sort><creationdate>20250117</creationdate><title>Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas</title><author>Sato, Masaya ; Tateishi, Ryosuke ; Zohar, Yogev ; Sato, Jiro ; Watadani, Takeyuki ; Moriyama, Makoto ; Wake, Taijiro ; Nakagomi, Ryo ; Kinoshita, Mizuki Nishibatake ; Nakatsuka, Takuma ; Minami, Tatsuya ; Uchino, Koji ; Enooku, Kenichiro ; Nakagawa, Hayato ; Asaoka, Yoshinari ; Yamada, Ryo ; Even, Nitzan ; Amitai, Inbal ; Abu, Yossi ; Fujishiro, Mitsuhiro ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3192-72392f1f7e5241aece1057eedd9ac43e70c19da610cb0b4a45189613596904353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Ablation</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Care and treatment</topic><topic>Catheter Ablation - methods</topic><topic>Computed tomography</topic><topic>Computer programs</topic><topic>Computer-assisted surgery</topic><topic>Damage</topic><topic>Evaluation</topic><topic>Female</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Image processing</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - surgery</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Navigation systems</topic><topic>Performance evaluation</topic><topic>Predictions</topic><topic>Radio frequency</topic><topic>Radiofrequency ablation</topic><topic>Radiofrequency Ablation - methods</topic><topic>Real time</topic><topic>Registration</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>Temperature</topic><topic>Thermal imaging</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - 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Academic</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Masaya</au><au>Tateishi, Ryosuke</au><au>Zohar, Yogev</au><au>Sato, Jiro</au><au>Watadani, Takeyuki</au><au>Moriyama, Makoto</au><au>Wake, Taijiro</au><au>Nakagomi, Ryo</au><au>Kinoshita, Mizuki Nishibatake</au><au>Nakatsuka, Takuma</au><au>Minami, Tatsuya</au><au>Uchino, Koji</au><au>Enooku, Kenichiro</au><au>Nakagawa, Hayato</au><au>Asaoka, Yoshinari</au><au>Yamada, Ryo</au><au>Even, Nitzan</au><au>Amitai, Inbal</au><au>Abu, Yossi</au><au>Fujishiro, Mitsuhiro</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2025-01-17</date><risdate>2025</risdate><volume>20</volume><issue>1</issue><spage>e0317469</spage><pages>e0317469-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC).
BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing the ablation zones it predicted with those annotated by radiologists using contrast-enhanced computed tomography (CECT) 24 hours post-treatment, considered the gold standard. The study included 20 liver tumors.
The median tumor measurement along the major axis was 1.2 cm. The median Dice coefficient, Sensitivity, and Precision between BioTrace and CECT were 0.90, 0.91, and 0.91, respectively. The intraclass correlation showed excellent agreement in volume size between BioTrace and CECT findings (0.98).
BioTrace effectively generates an ablation damage prediction map based on real-time ultrasound imaging, accurately predicting the ablation zone as confirmed by 24-hour post-procedural CECT. This system has the potential to enhance the safety and efficacy of ablation procedures in clinical settings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39823502</pmid><doi>10.1371/journal.pone.0317469</doi><tpages>e0317469</tpages><orcidid>https://orcid.org/0000-0002-2805-8226</orcidid><orcidid>https://orcid.org/0000-0003-3021-2517</orcidid><orcidid>https://orcid.org/0000-0002-4074-1140</orcidid><orcidid>https://orcid.org/0000-0001-5423-9664</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2025-01, Vol.20 (1), p.e0317469 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3156772935 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Ablation Aged Algorithms Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - surgery Care and treatment Catheter Ablation - methods Computed tomography Computer programs Computer-assisted surgery Damage Evaluation Female Hepatocellular carcinoma Hepatoma Humans Image processing Image Processing, Computer-Assisted - methods Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - surgery Magnetic resonance imaging Male Medical imaging Methods Middle Aged Navigation systems Performance evaluation Predictions Radio frequency Radiofrequency ablation Radiofrequency Ablation - methods Real time Registration Retrospective Studies Software Temperature Thermal imaging Tomography Tomography, X-Ray Computed - methods Tumors Ultrasonic imaging Ultrasonography - methods Ultrasound Ultrasound imaging |
| title | Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T00%3A27%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retrospective%20evaluation%20of%20a%20novel%20ultrasound-based%20imaging%20analysis%20software%20for%20predicting%20radiofrequency%20ablation%20areas&rft.jtitle=PloS%20one&rft.au=Sato,%20Masaya&rft.date=2025-01-17&rft.volume=20&rft.issue=1&rft.spage=e0317469&rft.pages=e0317469-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0317469&rft_dat=%3Cgale_plos_%3EA823938929%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3156772935&rft_id=info:pmid/39823502&rft_galeid=A823938929&rfr_iscdi=true |