CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells

In mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3. When cells enter mitosis, cytoplasmic microtubules are reorganized into the spindle composed of both centrosomal and non-centrosomal microt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2025-01, Vol.20 (1), p.e0308150
Hauptverfasser:	Nishizawa, Naoko, Arai, Riku, Hiranuma, Koki, Toya, Mika, Sato, Masamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Assembly Binding proteins Biology and Life Sciences Caco-2 Cells Cell division Chromatids Chromosome replication Chromosome Segregation Chromosomes Cloning CRISPR Epithelial cells Epithelial Cells - metabolism Epithelium Ethylenediaminetetraacetic acid Fibers Genetic aspects Genetic research Humans Insects Kinetochores Localization Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Mitosis Penicillin Phosphatase Physiological aspects Plasmids Polymerase chain reaction Protein binding Proteins Research and Analysis Methods Sister chromatids Spindle Apparatus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!