Early neutrophil activation and NETs release in the pristane-induced lupus mice model

NETosis is recognized as an important source of autoantigens. Therefore, we hypothesized whether the pristane-induced lupus mice model shows early activation of neutrophils, the presence of low-density granulocytes (LDGs), and neutrophil extracellular traps (NETs) release, which could contribute to...

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Veröffentlicht in:	PloS one 2025, Vol.20 (1), p.e0306943
Hauptverfasser:	Carrasco, Solange, Liphaus, Bernadete L, Peixoto, Tatiana Vasconcelos, Lima, Thais Martins, Ariga, Sueli Kunimi Kubo, Jesus Queiroz, Zelita Aparecida, de Matos Lobo, Thays, Catanozi, Sergio, Rodrigues, Letícia Gomes, Filho, Antônio Santos, Teodoro, Walcy Rosolia, Velosa, Ana Paula Pereira, Levy, Débora, Soriano, Francisco Garcia, Goldenstein-Schainberg, Cláudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens Autoimmune diseases Blood Bone marrow CD11b antigen Cell activation Cells Cloning Disease Models, Animal Extracellular Traps - immunology Extracellular Traps - metabolism Female Flow cytometry Granulocytes Granulocytes - immunology Granulocytes - metabolism Health aspects Immune response Injection Innate immunity Laboratory animals Lavage Leukocytes (granulocytic) Leukocytes (neutrophilic) Lupus Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Medical research Medicine, Experimental Mice Mice, Inbred BALB C Monoclonal antibodies Neutrophil Activation Neutrophils Neutrophils - immunology Peritoneum Phenotypes Physiological aspects Pristane Spleen Spleen - immunology Systemic lupus erythematosus Terpenes
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