Uncovering NK cell sabotage in gut diseases via single cell transcriptomics

The identification of immune environments and cellular interactions in the colon microenvironment is essential for understanding the mechanisms of chronic inflammatory disease. Despite occurring in the same organ, there is a significant gap in understanding the pathophysiology of ulcerative colitis...

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Veröffentlicht in:	PLOS ONE 2025-01, Vol.20 (1), p.e0315981
Hauptverfasser:	Lee, Hansong, Ko, Dai Sik, Heo, Hye Jin, Baek, Seung Eun, Kim, Eun Kyoung, Kwon, Eun Jung, Kang, Junho, Yu, Yeuni, Baryawno, Ninib, Kim, Kihun, Lee, Dongjun, Kim, Yun Hak
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biopsy Cancer Cancer therapies CD8 antigen CD8-Positive T-Lymphocytes - immunology Cells Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - pathology Colon Colon - immunology Colon - metabolism Colon - pathology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Communication Confocal microscopy Cytotoxicity Datasets Diseases Female Galectin-9 Galectins - genetics Galectins - metabolism Gene expression Gene sequencing Genetic aspects Genomics Health aspects Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Immune response Immune response (cell-mediated) Immune system Immunology Immunosurveillance Immunotherapy Inflammation Inflammatory bowel disease Inflammatory bowel diseases Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Lymphocytes Lymphocytes T Male Medical research Medicine, Experimental Microenvironments Middle Aged Myeloid cells Natural killer cells Oncology, Experimental Pathophysiology Physiological aspects Rectum RNA sequencing Sabotage Single-Cell Analysis Stomach diseases Therapeutic targets Tofacitinib Toxicity Transcriptome Transcriptomics Ulcerative colitis
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