Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells

Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia. Ketamine is an N-methyl-D-aspartate (NMDA) receptor...

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Veröffentlicht in:	PloS one 2025-01, Vol.20 (1), p.e0316262
Hauptverfasser:	Fleiner, Anne S, Kolnier, Daniel, Hagger-Vaughan, Nicholas, Ræder, Johan, Storm, Johan F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Action Potentials - drug effects Allosteric properties Anesthesia Anesthetics Anesthetics, Intravenous - pharmacology Animals Biology and Life Sciences Brain slice preparation Cholinergics Cognitive ability Consciousness Dosage and administration Dreams Drugs Fainting General anesthesia Glutamate receptors Glutamic acid receptors (ionotropic) Incubation Ketamine Ketamine - pharmacology Male Medicine and Health Sciences Muscarine Muscarine - pharmacology Muscarinic receptors N-Methyl-D-aspartic acid receptors Neocortex - cytology Neocortex - drug effects Neocortex - physiology Neuromodulation Patch-Clamp Techniques Physical Sciences Physiological aspects Physiology Prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Propofol Propofol - pharmacology Pyramidal cells Pyramidal Cells - drug effects Rats Receptors Spiking Testing Unconsciousness γ-Aminobutyric acid A receptors
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