The effect of KUS121, a novel VCP modulator, against ischemic injury in random pattern flaps

Surgery using skin flaps is essential for soft tissue reconstruction. However, postoperative ischemic injury of the skin flap is a major complication and a top concern after the surgery. Currently, evidence-based drugs to fully prevent ischemic injury are not available. The purpose of this study was...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0299882
Hauptverfasser:	Yoshimoto, Koichi, Ikeguchi, Ryosuke, Noguchi, Takashi, Ando, Maki, Sakamoto, Daichi, Iwai, Terunobu, Nishitani, Kohei, Ikeda, Hanako Ohashi, Kakizuka, Akira, Matsuda, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Apoptosis - drug effects Biology and Life Sciences Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Complications Complications and side effects Damage patterns Dosage and administration Drug development Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Enzyme inhibitors Flaps (Surgery) Gene expression Glucose Immunohistochemistry Injuries Injury prevention Ischemia Ischemia - drug therapy Laboratories Male Medicine and Health Sciences Necrosis Plastic surgery Postoperative Prevention Proteins Rats Rats, Sprague-Dawley Reconstructive surgery Risk factors Skin Skin & tissue grafts Skin injuries Soft tissues Surgery Surgical Flaps Testing Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Valosin Containing Protein - genetics Valosin Containing Protein - metabolism
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