Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation

Mild therapeutic hypothermia showed potential neuroprotective properties during and after cerebral hypoxia or ischemia in experimental animal studies. However, in clinical trials, where hypothermia is mainly applied after reperfusion, results were divergent and neurophysiological effects unclear. In...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0314913
Hauptverfasser:	Voogd, Eva J H F, Thijs, Marloes, Levers, Marloes R, Hofmeijer, Jeannette, Frega, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cardiac arrest Care and treatment Cell Differentiation Cell Hypoxia Cell Survival Cell viability Cells, Cultured Cerebral anoxia Clinical trials Dosage and administration Electrodes Fever Health aspects Humans Hyperthermia Hypothermia Hypothermia, Induced Hypothermia, Induced - methods Hypoxia Immunocytochemistry Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Ischemia Metabolism Microelectrodes Nerve Net Neural circuitry Neural networks Neural stem cells Neurons Neurons - metabolism Neuroprotection Oxygen - metabolism Patient outcomes Physiological aspects Pluripotency Recovery Recovery of function Reperfusion Stem cells Synapses - metabolism Synapses - physiology Temperature Testing
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