Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo
Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes. In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in K...
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| Veröffentlicht in: | PloS one 2024-12, Vol.19 (12), p.e0310339 |
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| creator | Leuba, Sequoia I Westreich, Daniel Bose, Carl L Olshan, Andrew F Taylor, Steve M Tshefu, Antoinette Lokangaka, Adrien Carlo, Waldemar A Chomba, Elwyn Mwenechanya, Musaku Liechty, Edward A Bucher, Sherri L Ekhaguere, Osayame A Esamai, Fabian Nyongesa, Paul Jessani, Saleem Saleem, Sarah Goldenberg, Robert L Moore, Janet L Nolen, Tracy L Hemingway-Foday, Jennifer McClure, Elizabeth M Koso-Thomas, Marion Derman, Richard J Hoffman, Matthew Meshnick, Steven R Bauserman, Melissa |
| description | Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.
In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.
Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].
First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight. |
| doi_str_mv | 10.1371/journal.pone.0310339 |
| format | Article |
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In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.
Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].
First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0310339</identifier><identifier>PMID: 39705264</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Anemia ; Aspirin ; Birth weight ; Clinical trials ; Complications and side effects ; Democratic Republic of the Congo - epidemiology ; Demographic aspects ; Education ; Enrollments ; Female ; Gestational age ; Hemoglobin ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infections ; Kenya - epidemiology ; Low birth weight ; Malaria ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - parasitology ; Miscarriage ; Mortality ; Parity ; Plasmodium falciparum - isolation & purification ; Polymerase chain reaction ; Population ; Pregnancy ; Pregnancy Complications, Parasitic - epidemiology ; Pregnancy Outcome ; Pregnancy Trimester, First ; Pregnancy, Complications of ; Premature birth ; Premature Birth - epidemiology ; Prevalence ; Risk factors ; Risk management ; Socioeconomic factors ; Socioeconomic status ; Stillbirth ; Vector-borne diseases ; Womens health ; Young Adult ; Zambia - epidemiology</subject><ispartof>PloS one, 2024-12, Vol.19 (12), p.e0310339</ispartof><rights>Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4319-857d3d459526fe38710e04fbeed19c2253c76501c441fc94be45ad458109aeff3</cites><orcidid>0000-0002-6585-2824 ; 0000-0003-3069-1650 ; 0000-0003-3236-6421</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0310339&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310339$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,862,2098,2917,23849,27907,27908,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39705264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Babah, Ochuwa Adiketu</contributor><creatorcontrib>Leuba, Sequoia I</creatorcontrib><creatorcontrib>Westreich, Daniel</creatorcontrib><creatorcontrib>Bose, Carl L</creatorcontrib><creatorcontrib>Olshan, Andrew F</creatorcontrib><creatorcontrib>Taylor, Steve M</creatorcontrib><creatorcontrib>Tshefu, Antoinette</creatorcontrib><creatorcontrib>Lokangaka, Adrien</creatorcontrib><creatorcontrib>Carlo, Waldemar A</creatorcontrib><creatorcontrib>Chomba, Elwyn</creatorcontrib><creatorcontrib>Mwenechanya, Musaku</creatorcontrib><creatorcontrib>Liechty, Edward A</creatorcontrib><creatorcontrib>Bucher, Sherri L</creatorcontrib><creatorcontrib>Ekhaguere, Osayame A</creatorcontrib><creatorcontrib>Esamai, Fabian</creatorcontrib><creatorcontrib>Nyongesa, Paul</creatorcontrib><creatorcontrib>Jessani, Saleem</creatorcontrib><creatorcontrib>Saleem, Sarah</creatorcontrib><creatorcontrib>Goldenberg, Robert L</creatorcontrib><creatorcontrib>Moore, Janet L</creatorcontrib><creatorcontrib>Nolen, Tracy L</creatorcontrib><creatorcontrib>Hemingway-Foday, Jennifer</creatorcontrib><creatorcontrib>McClure, Elizabeth M</creatorcontrib><creatorcontrib>Koso-Thomas, Marion</creatorcontrib><creatorcontrib>Derman, Richard J</creatorcontrib><creatorcontrib>Hoffman, Matthew</creatorcontrib><creatorcontrib>Meshnick, Steven R</creatorcontrib><creatorcontrib>Bauserman, Melissa</creatorcontrib><title>Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.
In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.
Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].
First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight.</description><subject>Adult</subject><subject>Anemia</subject><subject>Aspirin</subject><subject>Birth weight</subject><subject>Clinical trials</subject><subject>Complications and side effects</subject><subject>Democratic Republic of the Congo - epidemiology</subject><subject>Demographic aspects</subject><subject>Education</subject><subject>Enrollments</subject><subject>Female</subject><subject>Gestational age</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Kenya - epidemiology</subject><subject>Low birth weight</subject><subject>Malaria</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Miscarriage</subject><subject>Mortality</subject><subject>Parity</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Polymerase chain reaction</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - epidemiology</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy, Complications of</subject><subject>Premature birth</subject><subject>Premature Birth - epidemiology</subject><subject>Prevalence</subject><subject>Risk factors</subject><subject>Risk management</subject><subject>Socioeconomic factors</subject><subject>Socioeconomic status</subject><subject>Stillbirth</subject><subject>Vector-borne diseases</subject><subject>Womens health</subject><subject>Young Adult</subject><subject>Zambia - 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Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leuba, Sequoia I</au><au>Westreich, Daniel</au><au>Bose, Carl L</au><au>Olshan, Andrew F</au><au>Taylor, Steve M</au><au>Tshefu, Antoinette</au><au>Lokangaka, Adrien</au><au>Carlo, Waldemar A</au><au>Chomba, Elwyn</au><au>Mwenechanya, Musaku</au><au>Liechty, Edward A</au><au>Bucher, Sherri L</au><au>Ekhaguere, Osayame A</au><au>Esamai, Fabian</au><au>Nyongesa, Paul</au><au>Jessani, Saleem</au><au>Saleem, Sarah</au><au>Goldenberg, Robert L</au><au>Moore, Janet L</au><au>Nolen, Tracy L</au><au>Hemingway-Foday, Jennifer</au><au>McClure, Elizabeth M</au><au>Koso-Thomas, Marion</au><au>Derman, Richard J</au><au>Hoffman, Matthew</au><au>Meshnick, Steven R</au><au>Bauserman, Melissa</au><au>Babah, Ochuwa Adiketu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-12-20</date><risdate>2024</risdate><volume>19</volume><issue>12</issue><spage>e0310339</spage><pages>e0310339-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.
In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.
Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].
First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39705264</pmid><doi>10.1371/journal.pone.0310339</doi><tpages>e0310339</tpages><orcidid>https://orcid.org/0000-0002-6585-2824</orcidid><orcidid>https://orcid.org/0000-0003-3069-1650</orcidid><orcidid>https://orcid.org/0000-0003-3236-6421</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-12, Vol.19 (12), p.e0310339 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3147654895 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Anemia Aspirin Birth weight Clinical trials Complications and side effects Democratic Republic of the Congo - epidemiology Demographic aspects Education Enrollments Female Gestational age Hemoglobin Humans Infant, Low Birth Weight Infant, Newborn Infections Kenya - epidemiology Low birth weight Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Miscarriage Mortality Parity Plasmodium falciparum - isolation & purification Polymerase chain reaction Population Pregnancy Pregnancy Complications, Parasitic - epidemiology Pregnancy Outcome Pregnancy Trimester, First Pregnancy, Complications of Premature birth Premature Birth - epidemiology Prevalence Risk factors Risk management Socioeconomic factors Socioeconomic status Stillbirth Vector-borne diseases Womens health Young Adult Zambia - epidemiology |
| title | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T04%3A41%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20on%20maternal%20and%20pregnancy%20outcomes%20of%20first-trimester%20malaria%20infection%20among%20nulliparous%20women%20from%20Kenya,%20Zambia,%20and%20the%20Democratic%20Republic%20of%20the%20Congo&rft.jtitle=PloS%20one&rft.au=Leuba,%20Sequoia%20I&rft.date=2024-12-20&rft.volume=19&rft.issue=12&rft.spage=e0310339&rft.pages=e0310339-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0310339&rft_dat=%3Cgale_plos_%3EA820702493%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3147654895&rft_id=info:pmid/39705264&rft_galeid=A820702493&rft_doaj_id=oai_doaj_org_article_b71de5cab39b4876965b164d08c92050&rfr_iscdi=true |