Tin prefiltration in computed tomography does not significantly alter radiation-induced gene expression and DNA double-strand break formation

The tin (Sn) prefilter technique is a recently introduced dose-saving technique in computed tomography (CT). This study investigates whether there is an altered molecular biological response in blood cells using the tin prefiltering technique. Blood from 6 donors was X-irradiated ex-vivo with 20 mGy...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0315808
Hauptverfasser:	Schüle, Simone, Hackenbroch, Carsten, Beer, Meinrad, Ostheim, Patrick, Hermann, Cornelius, Muhtadi, Razan, Stewart, Samantha, Port, Matthias, Scherthan, Harry, Abend, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Blood & organ donations Blood cells Computed tomography Consent CT imaging Deoxyribonucleic acid Diagnostic equipment (Medical) DNA DNA Breaks, Double-Stranded - radiation effects DNA damage Dose-response relationship (Biochemistry) Dose-Response Relationship, Radiation Double-strand break repair Energy Ethylenediaminetetraacetic acid Female Gene expression Gene Expression Regulation - radiation effects Genes Genetic transcription Germanium Humans Image quality Influence Male Medical imaging Methods MicroRNA MicroRNAs - genetics miRNA Physiological aspects Post-transcription Radiation Radiation dosage Radiation effects Ribonucleic acid RNA Scanners Tin Tomography Tomography, X-Ray Computed - methods X-rays
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