Evolution of two metabolic genes involved in nucleotide and amino acid metabolism in Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic human pathogen causing various severe infections. Understanding genetic mechanisms of its metabolic versatility aids in developing novel antibacterial drugs and therapeutic strategies to address multidrug-resistant P. aeruginosa infections. The metabolism o...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0315931
Hauptverfasser:	Wu, Yutong, Shi, Yuqi, Liang, Xiaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Adaptation Amino acids Amino Acids - metabolism Analysis Antibacterial agents Antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism Biofilms Biology and Life Sciences Computer and Information Sciences Copy number Deamination Distribution patterns Divergence Drug metabolism Evolution Evolution, Molecular Evolutionary genetics Functionals Gene Expression Regulation, Bacterial Genes Genetic aspects Genomes Genomics Guanine deaminase Health aspects Homeostasis Immune response Immunosuppressive agents Infection Infections Medicine and Health Sciences Metabolism Multidrug resistance Nucleotides Nucleotides - genetics Nucleotides - metabolism Opportunist infection Pathogens Phylogenetics Phylogeny Physiological aspects Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Sepsis Transcription factors
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