Physiological consequences of Aldolase C deficiency during lactation

The lactating mammary gland strongly induces de novo lipogenesis (DNL) to support the synthesis of fatty acids, triglycerides, and cholesterol found within milk. In monogastric species, glucose is a major substrate utilized for DNL within the lactating mammary gland and must be efficiently taken up...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0315719
Hauptverfasser:	Votava, James A, Fan, Jing, Parks, Brian W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldolase Analysis Animals Binding proteins Biochemical analysis Biology and Life Sciences Body weight Breast milk Carbohydrates Cholesterol Cholesterol - metabolism Dextrose Enzymes Fatty acids Female Fructose-Bisphosphate Aldolase - deficiency Fructose-Bisphosphate Aldolase - genetics Fructose-Bisphosphate Aldolase - metabolism Galactose Genes Glucose Glycolysis Histology Impact analysis Lactation Lactation - metabolism Lactose Lipids Lipogenesis Liver Mammary gland Mammary glands Mammary Glands, Animal - metabolism Mass spectrometry Mass spectroscopy Medicine and Health Sciences Mice Mice, Knockout Milk Milk - metabolism Oxidation Physical Sciences Physiology Protein binding Proteins Regulatory sequences Suckling behavior Synthesis Transcription Triglycerides Triglycerides - metabolism Zebrin II
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