Lower serum uric acid levels are associated with depressive symptoms in a Japanese general population: A population-based cross-sectional study
Uric acid (UA) is a final product of purine metabolism and has neuroprotective effects. It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population....
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| creator | Takekawa, Daiki Kinoshita, Hirotaka Nikaido, Yoshikazu Kudo, Takashi Mikami, Tatsuya Hirota, Kazuyoshi |
| description | Uric acid (UA) is a final product of purine metabolism and has neuroprotective effects. It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population. We used the Iwaki Health Promotion Project 2022 data (737 subjects) in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the prevalence of depressive symptoms. Subjects with CES-D scores ≥16 were assigned to the Depression group. We compared characteristics and laboratory data (including serum UA) between the Depression and Non-depression groups and performed a multivariable logistic regression analysis to investigate whether their serum UA levels were associated with depressive symptoms, after adjusting for possible confounding factors. We analyzed the cases of 705 subjects: the Depression group (n = 142) and the Non-depression group (n = 563). The Depression group's serum UA levels were significantly lower than those of the Non-depression group. The multivariable logistic regression analysis demonstrated that lower serum UA levels were significantly associated with the depressive symptoms. In conclusion, lower serum UA levels in this Japanese general population were significantly associated with the depressive symptoms. |
| doi_str_mv | 10.1371/journal.pone.0311971 |
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It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population. We used the Iwaki Health Promotion Project 2022 data (737 subjects) in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the prevalence of depressive symptoms. Subjects with CES-D scores ≥16 were assigned to the Depression group. We compared characteristics and laboratory data (including serum UA) between the Depression and Non-depression groups and performed a multivariable logistic regression analysis to investigate whether their serum UA levels were associated with depressive symptoms, after adjusting for possible confounding factors. We analyzed the cases of 705 subjects: the Depression group (n = 142) and the Non-depression group (n = 563). The Depression group's serum UA levels were significantly lower than those of the Non-depression group. The multivariable logistic regression analysis demonstrated that lower serum UA levels were significantly associated with the depressive symptoms. In conclusion, lower serum UA levels in this Japanese general population were significantly associated with the depressive symptoms.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0311971</identifier><identifier>PMID: 39661619</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Biology and Life Sciences ; Bipolar disorder ; Blood ; Creatinine ; Cross-Sectional Studies ; Cytokines ; Depression - blood ; Depression - epidemiology ; Depression, Mental ; Diabetes ; Diagnosis ; Disease ; East Asian People ; Epidemiology ; Female ; Health aspects ; Health promotion ; Hemoglobin ; Humans ; Hypertension ; Japan - epidemiology ; Male ; Medicine and Health Sciences ; Mental depression ; Middle Aged ; Neuroprotection ; Physical Sciences ; Population ; Population studies ; Prevalence ; Psychological aspects ; Regression analysis ; Research and Analysis Methods ; Risk factors ; Tumor necrosis factor-TNF ; Uric acid ; Uric Acid - blood</subject><ispartof>PloS one, 2024-12, Vol.19 (12), p.e0311971</ispartof><rights>Copyright: © 2024 Takekawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Takekawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Takekawa et al 2024 Takekawa et al</rights><rights>2024 Takekawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5236-3e2d7ad0ebcce54d7c7493081c43b0697836b578f7c34d78ae10e308a97cea6a3</cites><orcidid>0000-0001-7912-6228 ; 0000-0003-4005-9536 ; 0000-0003-4490-3941 ; 0000-0002-6657-6446</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633994/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633994/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39661619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hashimoto, Kenji</contributor><creatorcontrib>Takekawa, Daiki</creatorcontrib><creatorcontrib>Kinoshita, Hirotaka</creatorcontrib><creatorcontrib>Nikaido, Yoshikazu</creatorcontrib><creatorcontrib>Kudo, Takashi</creatorcontrib><creatorcontrib>Mikami, Tatsuya</creatorcontrib><creatorcontrib>Hirota, Kazuyoshi</creatorcontrib><title>Lower serum uric acid levels are associated with depressive symptoms in a Japanese general population: A population-based cross-sectional study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Uric acid (UA) is a final product of purine metabolism and has neuroprotective effects. It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population. We used the Iwaki Health Promotion Project 2022 data (737 subjects) in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the prevalence of depressive symptoms. Subjects with CES-D scores ≥16 were assigned to the Depression group. We compared characteristics and laboratory data (including serum UA) between the Depression and Non-depression groups and performed a multivariable logistic regression analysis to investigate whether their serum UA levels were associated with depressive symptoms, after adjusting for possible confounding factors. We analyzed the cases of 705 subjects: the Depression group (n = 142) and the Non-depression group (n = 563). 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It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population. We used the Iwaki Health Promotion Project 2022 data (737 subjects) in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the prevalence of depressive symptoms. Subjects with CES-D scores ≥16 were assigned to the Depression group. We compared characteristics and laboratory data (including serum UA) between the Depression and Non-depression groups and performed a multivariable logistic regression analysis to investigate whether their serum UA levels were associated with depressive symptoms, after adjusting for possible confounding factors. We analyzed the cases of 705 subjects: the Depression group (n = 142) and the Non-depression group (n = 563). The Depression group's serum UA levels were significantly lower than those of the Non-depression group. The multivariable logistic regression analysis demonstrated that lower serum UA levels were significantly associated with the depressive symptoms. In conclusion, lower serum UA levels in this Japanese general population were significantly associated with the depressive symptoms.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39661619</pmid><doi>10.1371/journal.pone.0311971</doi><tpages>e0311971</tpages><orcidid>https://orcid.org/0000-0001-7912-6228</orcidid><orcidid>https://orcid.org/0000-0003-4005-9536</orcidid><orcidid>https://orcid.org/0000-0003-4490-3941</orcidid><orcidid>https://orcid.org/0000-0002-6657-6446</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biology and Life Sciences Bipolar disorder Blood Creatinine Cross-Sectional Studies Cytokines Depression - blood Depression - epidemiology Depression, Mental Diabetes Diagnosis Disease East Asian People Epidemiology Female Health aspects Health promotion Hemoglobin Humans Hypertension Japan - epidemiology Male Medicine and Health Sciences Mental depression Middle Aged Neuroprotection Physical Sciences Population Population studies Prevalence Psychological aspects Regression analysis Research and Analysis Methods Risk factors Tumor necrosis factor-TNF Uric acid Uric Acid - blood |
| title | Lower serum uric acid levels are associated with depressive symptoms in a Japanese general population: A population-based cross-sectional study |
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