Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity

Both enhanced motion-induced nausea and increased static imbalance are observed symptoms in migraine and especially vestibular migraine (VM). Motion-induced nausea and static imbalance were investigated in a mouse model, nestin/hRAMP1, expressing elevated levels of human RAMP1 which enhances CGRP si...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0313482
Hauptverfasser:	Rahman, Shafaqat M, Guo, Linda Jia, Minarovich, Carissa, Moon, Laura, Guo, Anna, Luebke, Anne E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Biology and Life Sciences Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - genetics Calcitonin Gene-Related Peptide - metabolism Center of pressure Disease Models, Animal Female Headache Human motion Humans Hypothermia Male Males Medicine and Health Sciences Mice Mice, Transgenic Migraine Migraine Disorders - drug therapy Migraine Disorders - genetics Migraine Disorders - metabolism Migraine Disorders - physiopathology Nausea Nausea - drug therapy Nausea - genetics Nervous system Nestin Peptides Posture Proteins Receptor activity modifying proteins Receptor Activity-Modifying Protein 1 - genetics Receptor Activity-Modifying Protein 1 - metabolism Research and Analysis Methods Sensitivity analysis Social Sciences Temperature Thermoregulation Vertigo Vestibular system
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